Mediastinal malignant lymphoma.

Ninety-seven cases of mdipant lymphoma, clinically presenting in tbe mediadomu, were dhgmd by examination of smgical pathologic specimens, These specimens were aaalyzed in the light of newer concepts regarding lymphoma, hch~dhg current Elanrrification and clinical staging of these tamor& The influences of clinkal and histopatbo1ogic features and therapentic mod& tiea were assessed in regard to prognosis. FWy-seven patients bad Hodgkin's disease and 613 percent of these patients survived five years, whereas 40 patients had lymphosareomas and only 15 percent of these patients sorvived five year& Generally, matme lympbocylic predominance of lympbonum md nodnlarity, particPtarly in lympbosarcoma, were histopatbologic features that were assodated with increased survival. Nodular sclerosis was noted in 35 of the patients and mixed cellular@ in 19, and these patients had favorable snrvival rates. Thirteen of the 15 patients with lymphoma of stage I survived five year& Five of the six patients with thymic HodgWs disease treated by surgical excision and roentgen therapy survived five years or more. Radical surgery has a distinct place in the therapy of selected patients with medinstinal lymphoma.